Endocrine Abstracts

Diabetes mellitus is a leading cause of chronic renal insufficiency and later end-stage renal failure; on the other hand, chronic renal disease has been linked with alterations in carbohydrate and insulin metabolism. The pharmacokinetics of various insulin preparations has not been well studied in patients with varying degrees of renal dysfunction. There exist sparse guidelines regarding appropriate dosing adjustment of insulin. Further, chronic renal insufficiency is associat...